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Published on: September 19, 2016
B lymphocytes in anti-mycobacterial immune responses: Pathogenesis or protection?
Alexander V Dyatlov1, Alexander S Apt2, Irina A Linge1
1Laboratory for Immunogenetics, Central Institute for Tuberculosis, Moscow, Russia.
Abstract:
The role of B cells and antibodies in tuberculosis (TB) immunity, protection and pathogenesis remain contradictory. The presence of organized B cell follicles close to active TB lesions in the lung tissue raises the question about the role of these cells in local host-pathogen interactions. In this short review, we summarize the state of our knowledge concerning phenotypes of B cells populating tuberculous lungs, their secretory activity, interactions with other immune cells and possible involvement in protective vs. pathogenic TB immunity.
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