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Effects of nongaussian diffusion on "isotropic diffusion" measurements: An ex-vivo microimaging and simulation study

Sune Nørhøj Jespersen1, Jonas Lynge Olesen1, Andrada Ianuş2

  • 1Center of Functionally Integrative Neuroscience (CFIN) and MINDLab, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Physics and Astronomy, Aarhus University, Aarhus, Denmark.

Journal of Magnetic Resonance (San Diego, Calif. : 1997)
|February 4, 2019
PubMed
Summary

Deviations from Gaussian diffusion models in MRI can lead to inaccurate measurements of tissue microstructure. This study reveals how non-Gaussian effects confound orientation dispersion and kurtosis, impacting isotropic diffusivity calculations.

Keywords:
DiffusionDispersionKurtosisTime-dependenceqMAS

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