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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Hypertension I: Introduction01:28

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Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
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Hypertension II: Pathophysiology01:29

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Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
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Hypertension V: Nursing Management01:23

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The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
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Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
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Pulmonary Hypertension: Classification and Pathogenesis01:30

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Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
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A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases
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Autoimmune Disease-Associated Hypertension.

Victoria L Wolf1, Michael J Ryan2,3

  • 1Department of Physiology & Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216-4505, USA.

Current Hypertension Reports
|February 4, 2019
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Summary

Autoimmune diseases increase hypertension risk through inflammation and autoantibodies. Future research should explore sex hormones, neutrophils, and mitochondrial dysfunction in this complex relationship.

Keywords:
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Area of Science:

  • Immunology
  • Cardiovascular Medicine
  • Nephrology

Background:

  • Autoimmune diseases like lupus and rheumatoid arthritis are linked to higher hypertension and cardiovascular disease risk.
  • Complex factors including genetics, environment, hormones, and metabolism contribute to autoimmune disease and hypertension.
  • Chronic inflammation from autoimmune conditions can lead to significant blood pressure alterations.

Purpose of the Study:

  • To review key findings on autoimmune disease-associated hypertension.
  • To highlight the mechanistic role of autoantibodies in this condition.
  • To identify future research directions, including sex hormones, neutrophils, and mitochondrial dysfunction.

Main Methods:

  • Literature review of recent studies on autoimmune disease and hypertension.
  • Analysis of immune system dysfunction's impact on vascular and renal function.
  • Examination of oxidative stress as a contributing factor.

Main Results:

  • Autoimmune diseases significantly elevate hypertension risk.
  • Autoantibodies play a crucial mechanistic role in autoimmune disease-associated hypertension.
  • Immune system dysfunction impacts vascular and renal hemodynamics, mediated by oxidative stress.

Conclusions:

  • Understanding the interplay between autoimmune disease and hypertension is critical.
  • Further research into sex hormones, neutrophils, and mitochondrial dysfunction is warranted.
  • Targeting immune pathways and oxidative stress may offer therapeutic strategies.