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Vertebrate hox temporal collinearity: does it exist and what is it's function?

A J Durston1

  • 1a Institute of Biology , University of Leiden, Sylvius Laboratory , Leiden , Netherlands.

Cell Cycle (Georgetown, Tex.)
|February 5, 2019
PubMed
Summary
This summary is machine-generated.

Hox temporal collinearity (TC) is crucial for embryonic development, establishing the basis for spatial patterns. This article reaffirms TC

Keywords:
Hox genesanterior-posterior (A-P) patterningdevelopmental timing

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Area of Science:

  • Developmental biology
  • Genetics
  • Evolutionary biology

Background:

  • Hox genes pattern the anterior-posterior (A-P) axis in vertebrates.
  • Hox temporal collinearity (TC) is a proposed mechanism for this patterning.
  • Recent studies have challenged the existence of TC.

Purpose of the Study:

  • To examine the recent challenge to Hox TC.
  • To present evidence supporting the existence of Hox TC.
  • To discuss the function and mechanism of TC.

Main Methods:

  • Review of existing literature and experimental data.
  • Analysis of evidence for and against TC.
  • Examination of the time-space translation mechanism.

Main Results:

  • Evidence strongly supports the continued existence of Hox TC.
  • TC is essential for establishing Hox spatial collinearity.
  • TC provides the foundation for the vertebrate A-P axial pattern.

Conclusions:

  • Hox TC is a fundamental principle in embryogenesis.
  • Understanding TC is key to understanding axial patterning.
  • The time-space translation mechanism requires further investigation.