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Role of vitamins in urolithiasis
A Khanam1, B Rahman, M A Rahman
1Department of Biochemistry, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|January 1, 1988
Summary
This study found low serum vitamin A in patients with urolithiasis, despite similar dietary intake. Vitamin B6 deficiency was ruled out as a cause for kidney stones.
Area of Science:
- Biochemistry
- Nutritional Science
- Urology
Background:
- Urolithiasis (kidney stone disease) affects a significant portion of the population.
- The role of specific vitamin deficiencies in urolithiasis pathogenesis requires further investigation.
Purpose of the Study:
- To investigate serum vitamin A and C levels in urolithiasis patients.
- To assess the impact of L-tryptophan and glycine supplementation on urinary oxalate and xanthurenic acid levels.
- To determine if vitamin B6 deficiency is associated with urolithiasis.
Main Methods:
- Serum levels of vitamin A and vitamin C were measured in patients with urolithiasis and control subjects.
- Oral supplementation with L-tryptophan and glycine was administered to both groups.
- Urinary oxalate and xanthurenic acid levels were monitored post-supplementation.
Main Results:
- Patients with urolithiasis exhibited lower serum vitamin A levels compared to controls.
- No significant difference in serum vitamin C levels was observed between groups.
- Oral L-tryptophan and glycine supplementation did not lead to increased urinary oxalate or xanthurenic acid.
Conclusions:
- Low serum vitamin A may be associated with urolithiasis, independent of dietary intake.
- Vitamin B6 deficiency is unlikely to be a contributing factor in the studied urolithiasis cases.