Related Experiment Video

Updated: Jan 29, 2026

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis
08:55

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis

Published on: August 7, 2018

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The role of necroptosis in cancer: A double-edged sword?

Xia Qin1, Dan Ma2, Ye-Xiong Tan1

  • 1National Center for Liver Cancer, Shanghai, China; The International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.

Biochimica Et Biophysica Acta. Reviews on Cancer
|February 5, 2019
PubMed

Insights

Necroptosis, a programmed cell death, can promote or inhibit tumors. Triggering necroptosis in cancer cells is a promising therapeutic strategy for cancer treatment.

Area of Science:

  • Cellular biology
  • Immunology
  • Oncology

Background:

  • Necroptosis is a programmed, caspase-independent cell death pathway.
  • Necroptosis differs from apoptosis by inducing inflammation via damage-associated molecular patterns.
  • Tumor cells can undergo necroptosis in vivo, influencing cancer progression.

Purpose of the Study:

  • To review recent research on necroptosis's dual role in cancer.
  • To explore the potential of necroptosis induction as a cancer therapy.

Main Methods:

  • Literature review of recent studies on necroptosis in cancer.
  • Analysis of necroptosis's pro- and anti-tumoral effects.
  • Evaluation of necroptosis-inducing agents in preclinical and clinical settings.

Main Results:

  • Necroptosis exhibits context-dependent pro- or anti-tumoral effects.
  • Inducing necroptosis can lead to tumor suppression.
  • Necroptosis can also promote tumor growth and metastasis in certain contexts.

Conclusions:

  • Necroptosis plays a complex role in cancer development and progression.
  • Targeting necroptosis is a viable therapeutic strategy for cancer treatment.
  • Further research is needed to fully elucidate necroptosis's mechanisms and optimize its therapeutic application.
Keywords:
CancerMLKLMetastasisNecroptosisRIPK3

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