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Lower femoral neck bone mineral density (BMD) in elderly women not on statins

Simbo M Chiadika1, Fisayomi O Shobayo1, Syed H Naqvi1

  • 1Department of Internal Medicine, UTHealth McGovern Medical School , Houston , Texas , USA.

Women & Health
|February 6, 2019
PubMed

Insights

Statins may help prevent bone loss in elderly women with coronary artery disease (CAD). This study found statin users had similar bone mineral density (BMD) to controls, suggesting a protective effect against bone loss in women with CAD.

Area of Science:

  • Gerontology
  • Cardiology
  • Endocrinology

Background:

  • Coronary artery disease (CAD) and osteoporosis are prevalent chronic diseases in aging populations.
  • Shared risk factors include hormonal changes, smoking, and inactivity.
  • CAD and low bone mineral density (BMD) show a strong association.

Purpose of the Study:

  • To examine the association between BMD and statin use in elderly women with or without CAD.
  • To investigate if statins influence BMD in older women.

Main Methods:

  • Cross-sectional study of 185 women aged 60+ referred to a geriatric osteoporosis clinic.
  • Multivariate regression analyses were used to compare BMD between groups.
  • Groups included: controls (no CAD, no statin), CAD with no statin, and statin users (with or without CAD).

Main Results:

  • Women with CAD and no statin use had significantly lower femoral neck BMD compared to controls.
  • BMD in statin users, irrespective of CAD status, was comparable to the control group.
  • Statins appeared to mitigate the negative impact of CAD on BMD.

Conclusions:

  • Statin use may be protective against bone loss in elderly women, particularly those with CAD.
  • Further prospective studies are needed to confirm the dual benefit of statins for cardiovascular and bone health.

Keywords:
Womencoronary artery disease (CAD)elderlyosteoporosisstatins

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