Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Evidence for Evolution02:55

The Evidence for Evolution

48.0K
Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
48.0K
Convergent Evolution01:54

Convergent Evolution

32.8K
Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.
32.8K
Eukaryotic Evolution01:24

Eukaryotic Evolution

40.9K
The endosymbiont theory is the most widely accepted theory of eukaryotic evolution; however, its progression is still somewhat debated. According to the nucleus-first hypothesis, the ancestral prokaryote first evolved a membrane to enclose DNA and form the nucleus. Conversely, the mitochondria-first hypothesis suggests that the nucleus was formed after endosymbiosis of mitochondria.
Contrary to the endosymbiont theory, the eukaryote-first hypothesis proposes that the simpler prokaryotic and...
40.9K
Synteny and Evolution02:31

Synteny and Evolution

3.8K
John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...
3.8K
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

3.7K
3.7K
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

8.2K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
8.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative analysis of the cellular landscape in mammalian striatum.

Nature communications·2026
Same author

Homologous specialization of arcuate fasciculus ventrolateral frontal connectivity in marmosets and humans.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Morphological and anatomical variations in subcortical anatomy between humans and chimpanzees associated with heritability patterns related to human behavioral traits.

Communications biology·2026
Same author

Mixed Signals and Interspecies Variation in the Plasticity of Adult Mammal Brains.

Cells·2026
Same author

Human-specific features of the cerebellum and ZP2-regulated synapse development.

Cell·2026
Same author

Changes in microglial morphologies during brain aging in common marmosets.

Brain structure & function·2026
Same journal

Increased rates of hybridization in swordtails are associated with water pollution.

Current biology : CB·2026
Same journal

Visual uncertainty and task demands shape active sensing strategies in mice.

Current biology : CB·2026
Same journal

An adaptable, self-organizing, single-cell morphology circuit optimizes suctorian predatory trap structure.

Current biology : CB·2026
Same journal

Temporal tuning of switch-like virulence expression resolves environmental uncertainty through phenotypic heterogeneity.

Current biology : CB·2026
Same journal

An abstract relational map emerges in the human medial prefrontal cortex with consolidation.

Current biology : CB·2026
Same journal

Phloem evolved gradually and asynchronously to xylem in early vascular plants.

Current biology : CB·2026
See all related articles

Related Experiment Video

Updated: Jan 29, 2026

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
13:12

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

46.5K

Brain Evolution: Mapping the Inner Neandertal.

Chet C Sherwood1, Brenda J Bradley1

  • 1Department of Anthropology and Center for the Advanced Study of Human Paleobiology, The George Washington University, USA.

Current Biology : CB
|February 6, 2019
PubMed
Summary
This summary is machine-generated.

Neandertal gene variants influenced modern human brain shape following ancient interbreeding events. This research explores the genetic underpinnings of the distinctively globular human brain shape.

More Related Videos

Brain Mapping Using a Graphene Electrode Array
10:32

Brain Mapping Using a Graphene Electrode Array

Published on: October 20, 2023

2.3K
Non-Invasive Modulation and Robotic Mapping of Motor Cortex in the Developing Brain
08:26

Non-Invasive Modulation and Robotic Mapping of Motor Cortex in the Developing Brain

Published on: July 1, 2019

7.1K

Related Experiment Videos

Last Updated: Jan 29, 2026

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
13:12

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

46.5K
Brain Mapping Using a Graphene Electrode Array
10:32

Brain Mapping Using a Graphene Electrode Array

Published on: October 20, 2023

2.3K
Non-Invasive Modulation and Robotic Mapping of Motor Cortex in the Developing Brain
08:26

Non-Invasive Modulation and Robotic Mapping of Motor Cortex in the Developing Brain

Published on: July 1, 2019

7.1K

Area of Science:

  • Paleogenetics
  • Human Evolution
  • Neuroscience

Background:

  • Modern humans interbred with Neandertals after migrating out of Africa.
  • Neandertal DNA is present in the genomes of non-African human populations.
  • Brain shape is a key distinguishing feature of Homo sapiens.

Purpose of the Study:

  • To investigate the impact of Neandertal genetic variants on the brain shape of modern humans.
  • To understand the genomic contribution of Neandertals to human cranial morphology.

Main Methods:

  • Analysis of 3D skull shapes from modern human populations with varying Neandertal ancestry.
  • Genome-wide association studies (GWAS) to identify Neandertal DNA segments associated with brain shape traits.
  • Comparative genomics between modern humans and archaic hominins.

Main Results:

  • Specific Neandertal gene variants were found to correlate with differences in modern human brain shape.
  • These variants influence the development and morphology of brain regions, contributing to the globular brain form.
  • The study identified genomic regions where Neandertal introgression has shaped human brain evolution.

Conclusions:

  • Neandertal introgression played a role in shaping the unique brain shape of modern humans.
  • Understanding these genetic contributions provides insights into the evolutionary trajectory of the human brain.
  • This research highlights the complex interplay between archaic hominins and the genomic landscape of modern humans.