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Anti-MDA5 antibody-positive rapidly progressive interstitial pneumonia without cutaneous manifestations

Junichi Aoyama1, Hiroki Hayashi1, Chika Yajima1

  • 1Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Japan.

Respiratory Medicine Case Reports
|February 7, 2019
PubMed

Insights

This case study highlights anti-melanoma differentiation-associate gene (anti-MDA5) antibody-positive interstitial pneumonia. Early detection is crucial, even without typical skin symptoms, in patients with rapidly progressive interstitial lung disease (RP-ILD) and high ferritin.

Area of Science:

  • Pulmonology
  • Rheumatology
  • Immunology

Background:

  • Rapidly progressive interstitial lung disease (RP-ILD) presents a diagnostic challenge.
  • Dermatomyositis-associated interstitial pneumonia often involves characteristic skin findings.
  • Anti-melanoma differentiation-associate gene (anti-MDA5) antibody is increasingly recognized in ILD, sometimes without skin manifestations.
Keywords:
ARS, anti-aminoacyl-tRNA synthetaseAnti-MDA5, anti-melanoma differentiation-associate geneAnti-melanoma differentiation-associated gene 5 antibodyCADM, clinically amyopathic dermatomyositisClinical amyopathic dermatomyositisExtracorporeal membrane oxygenationHRCT, high-resolution computed tomographyIVCY, intravenous cyclophosphamideRIG-I, retinoic acid inducible gene-IRP-ILD, rapidly progressive interstitial lung diseaseRapidly progressive interstitial pneumonia

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