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The diagnostic value of ischaemia-modified albumin in acute abdominal pain

Fatma Sarac1, Selman Yeniocak2, Sevgi Buyukbese Sarsu3

  • 1Department of Pediatric Surgery, Haseki Research and Education Hospital, Istanbul, Turkey.

Journal of Paediatrics and Child Health
|February 7, 2019
PubMed

Insights

Ischaemia-modified albumin (IMA), alongside white blood cell (WBC) and C-reactive protein (CRP), shows promise in diagnosing acute abdominal pain in children. These biomarkers help differentiate surgical from non-surgical causes in pediatric emergency settings.

Area of Science:

  • Pediatric Emergency Medicine
  • Biomarker Discovery
  • Diagnostic Accuracy

Background:

  • Acute abdominal pain in children presents diagnostic challenges in emergency departments.
  • Differentiating surgical from non-surgical causes is critical for timely intervention.

Purpose of the Study:

  • To evaluate the diagnostic utility of ischaemia-modified albumin (IMA) in pediatric acute abdominal pain.
  • To assess IMA's ability to distinguish surgical from non-surgical abdominal conditions in children.

Main Methods:

  • A study involving 112 pediatric patients with abdominal pain and 40 healthy controls.
  • Measurement of IMA, white blood cell (WBC), and C-reactive protein (CRP) levels in blood samples.

Main Results:

  • IMA levels were significantly elevated in patients with acute appendicitis (AA) and perforated appendicitis (PA) compared to controls and non-specific abdominal pain.
  • IMA levels did not differ significantly between AA and PA groups.
  • WBC and CRP levels were higher in AA and PA groups versus non-specific abdominal pain.

Conclusions:

  • IMA, in conjunction with WBC and CRP, can aid in the differential diagnosis of pediatric acute abdominal pain.
  • These biomarkers assist in distinguishing between surgical and non-surgical abdominal conditions in children.
Abstract

Keywords:
acute abdomenappendicitisischaemia-modified albuminpaediatrics

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