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Long-term Low-Dose Sucrose May Prevent Migraine: Two Double-Blinded Randomized Controlled Pilot Trials
Journal of Oral & Facial Pain and Headache
|February 7, 2019
Summary
This pilot study suggests that daily glucose may help prevent migraine attacks in college students. For adults, sucrose or fructose showed no significant preventive effect on migraine frequency.
Area of Science:
- Neurology
- Clinical Nutrition
Background:
- Migraine is a common neurological disorder impacting millions globally.
- Preventive treatments for migraine are crucial for improving patient quality of life.
Purpose of the Study:
- To evaluate the efficacy of sucrose in preventing migraine attacks.
- To compare sucrose with glucose or fructose in randomized pilot trials.
Main Methods:
- Two randomized double-blinded pilot trials were conducted in college students and adults.
- Participants received oral sucrose, glucose, or fructose daily for 3-6 months.
- Primary endpoint was migraine attack frequency; secondary endpoints included duration and severity.
Main Results:
- In students, glucose significantly reduced migraine frequency, while sucrose did not.
- In adults, neither sucrose nor fructose showed a significant difference in migraine frequency compared to controls.
- Secondary endpoints (duration, severity) improved over time in both trials, with no group differences.
Conclusions:
- Daily glucose may be effective in preventing migraine attacks in college students.
- Sucrose and fructose did not demonstrate significant migraine prevention benefits in adult trials.
- Further research is needed to confirm these findings and explore mechanisms.
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