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GDF11 is increased in patients with aplastic anemia
Xifeng Dong1, Yu Han2, Iruni Roshanie Abeysekera3
1a Department of Hematology, General Hospital , Tianjin Medical University , Tianjin , People's Republic of China.
Hematology (Amsterdam, Netherlands)
|February 8, 2019
Summary
Serum growth differentiation factor 11 (GDF11) levels are elevated in aplastic anemia (AA) patients and negatively correlate with hemoglobin and reticulocyte counts. This suggests an impaired GDF11 response contributes to anemia in AA.
Area of Science:
- Hematology
- Molecular Biology
- Cell Biology
Background:
- Aplastic anemia (AA) is a rare but serious bone marrow failure disorder.
- Growth differentiation factor 11 (GDF11) is a protein implicated in various biological processes, including aging and tissue regeneration.
Purpose of the Study:
- To investigate the role of GDF11 in the pathobiology of aplastic anemia.
- To assess GDF11 serum levels and mRNA expression in AA patients.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was used to measure serum GDF11 levels in 79 AA patients and 30 healthy controls.
- Real-time polymerase chain reaction (PCR) detected GDF11 mRNA expression in peripheral blood mononuclear cells (PBMNCs).
- Correlation analysis was performed between GDF11 levels and erythropoietic function markers.
Main Results:
- Untreated AA patients exhibited higher serum GDF11 levels compared to controls.
- GDF11 levels decreased after immunosuppressive therapy (IST) but did not normalize.
- Serum GDF11 levels showed a negative correlation with hemoglobin (Hb) and reticulocyte counts in AA patients.
Conclusions:
- Elevated serum GDF11 levels in AA patients suggest a potential role in disease pathogenesis.
- The negative correlation with Hb and reticulocytes indicates impaired GDF11 function may contribute to anemia in AA.
- Further research is warranted to elucidate the precise mechanisms of GDF11 in aplastic anemia.
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