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Cognitive function predicts work disability among multiple sclerosis patients.

Andrius Kavaliunas1, Petter Tinghög1,2, Emilie Friberg1

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Cognitive impairment in multiple sclerosis (MS) patients, measured by the Symbol Digit Modalities Test (SDMT), predicts future work disability. Lower SDMT scores indicate a higher risk of sickness absence or disability pension.

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Area of Science:

  • Neurology
  • Neuropsychology
  • Rehabilitation Medicine

Background:

  • Multiple sclerosis (MS) frequently impacts cognitive functions, affecting patients' employment and social lives.
  • Cognitive deficits in MS can lead to significant challenges in maintaining professional activities.

Purpose of the Study:

  • To investigate the predictive value of the Symbol Digit Modalities Test (SDMT) for work disability in multiple sclerosis (MS) patients.
  • To assess the relationship between cognitive performance and future employment status in individuals with MS.

Main Methods:

  • A register-based cohort study involving 903 MS patients.
  • Work disability (sickness absence/disability pension) data collected at baseline, 1-year, and 3-year follow-ups.
  • Statistical analysis using general estimating equations adjusted for demographic and clinical factors.

Main Results:

  • Patients with the lowest SDMT scores showed a 73% higher rate of work disability after one year compared to those with the highest scores (IRR 1.73).
  • This association remained consistent at the 3-year follow-up (IRR 1.68).

Conclusions:

  • Cognitive function, as assessed by the SDMT, is a significant predictor of future work disability in MS.
  • The findings highlight the importance of cognitive assessment in managing MS and its impact on employment.