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Antimicrobial susceptibility patterns of Nocardia asteroides
R J Wallace1, L C Steele, G Sumter
1Department of Microbiology, University of Texas Health Center, Tyler 75710.
Antimicrobial Agents and Chemotherapy
|December 1, 1988
Summary
Nocardia asteroides isolates showed limited antimicrobial susceptibility patterns. Amikacin, imipenem, ceftriaxone, cefotaxime, sulfonamides, and minocycline were the most effective agents against these bacteria.
Area of Science:
- Microbiology
- Infectious Diseases
Background:
- Nocardia asteroides is an opportunistic pathogen.
- Antimicrobial susceptibility testing is crucial for effective treatment.
Purpose of the Study:
- To determine the antimicrobial susceptibility patterns of Nocardia asteroides clinical isolates.
- To identify the most effective antimicrobial agents against Nocardia asteroides.
Main Methods:
- Broth microdilution method was used.
- Seventy-eight clinical isolates of Nocardia asteroides were tested.
- Susceptibility to 12 antimicrobial agents was evaluated.
Main Results:
- Ninety-five percent of isolates exhibited one of five susceptibility patterns.
- Most active parenteral agents included amikacin, imipenem, ceftriaxone, and cefotaxime.
- Most active oral agents included sulfonamides and minocycline.
Conclusions:
- Limited antimicrobial susceptibility patterns were observed in Nocardia asteroides.
- Sulfonamides, minocycline, amikacin, imipenem, ceftriaxone, and cefotaxime show significant activity.
- Further research is needed to understand beta-lactam resistance and taxonomic correlations.