Related Experiment Video
Updated: Jan 29, 2026

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis
Published on: May 23, 2021
A Diagnostic Challenge: Changes in Histopathologic Tumor Diagnosis of Atypical Squamous Proliferations After Surgical
Ashley G Rubin1,2, Shang I Brian Jiang3
1Veterans Affairs Hospital, Oceanside, California.
Background:
Biopsy-proven "atypical squamous proliferations" (ASPs) may prove difficult to diagnose histologically because of partial sampling, lack of complete criteria for definitive diagnosis, or overlap of histopathological features with other neoplasms. There are no guidelines concerning the management of ASPs.
Objective:
To retrospectively clarify the diagnosis of biopsy-proven ASPs after surgical removal, specifically, to ascertain what fraction represent malignant tumors.
Methods:
Medical records of patients who underwent surgical removal of biopsy-proven ASPs in an academic dermatologic surgical unit from June 2008 to July 2013 were examined. The resultant histopathologic diagnosis of these lesions after surgical removal, along with other demographic data, was obtained.
Results:
Of the 71 biopsy-proven ASPs that were treated by surgical removal in the study period, 54.9% exhibited resultant pathologic diagnosis of nonmelanoma skin cancer (NMSC).
Conclusion:
Biopsy-proven ASPs present a therapeutic challenge. The authors' data illustrate the importance of subsequent tissue sampling, as these lesions often represent NMSCs.
Related Concept Videos
Antipsychotic Drugs: Typical and Atypical Agents
Abnormal Proliferation
Nursing Diagnosis
The nursing diagnosis focuses on evidence-based...
Formulating and Validating Nursing Diagnosis I
There are thirteen domains...
Documentation of Nursing Diagnosis
In some settings, data-driven computerized decision support systems are in place, allowing for more accurate nursing diagnoses. The database within one of these systems includes diagnostic labels defining characteristics, activities, and indicators for nursing. A nurse enters...
Cells Coordinate Growth and Proliferation

