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Updated: Jan 29, 2026

Spectrophotometric Determination of Phycobiliprotein Content in Cyanobacterium Synechocystis
Published on: September 11, 2018
Minnamide A, a Linear Lipopeptide from the Marine Cyanobacterium Okeania hirsuta
Shimpei Sumimoto1, Masayuki Kobayashi1, Rio Sato1
1Department of Chemistry , Keio University , 3-14-1, Hiyoshi , Kohoku-ku, Yokohama , Kanagawa 223-8522 , Japan.
Abstract:
Minnamide A is a lipopeptide with a unique repeating structure consisting of hydroxy and proposed β-branched methyl groups. The absolute configuration of minnamide A was determined by a combination of chemical degradation, chiral HPLC analyses, and synthetic methods. Minnamide A showed growth-inhibitory activity toward HeLa cells with an IC50 value of 0.17 μM and rapidly induced cell death at a concentration of 2 μM. Minnamide A induced the copper-mediated accumulation of reactive oxygen species.
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