Related Experiment Video
Updated: Jan 29, 2026

Genome-wide Gene Deletions in Streptococcus sanguinis by High Throughput PCR
Published on: November 23, 2012
A deletion mutation within the ATBF1 gene is strongly associated with goat litter size
Ke Wang1, Yiqing Hui1, Shaoli Zhang1
1Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Abstract:
AT motif-binding factor (ATBF1) is a transcription factor that suppresses carcinogenesis and induces neuronal differentiation, as well as it directly interacts with estrogen receptor (ER) and regulates progesterone receptors signaling. Thus ATBF1 gene will possibly greatly affect reproductive tratis in animals. According to our available findings, two indel (insertion/deletion) variants (12-bp indel; 6-bp indel) within the ATBF1 gene were found in Shaanbei White cashmere goats (SWCG). The objective of this work was to investigate their association with litter size in Shaanbei White Cashmere goat. The association analyses uncovered that ATBF1-12bp indel was strongly related to the first-birth litter size in SWCG population (n = 1195, P = 1.0 × 10-3). Individuals with DD genotype (n = 445) had the best litter size when compared with those of ID genotype (n = 420) and DD genotype (n = 330). Besides, Chi-square tests of different litter size individuals showed that multi-kids individuals had higher "D" allelic frequencies and "DD" genotypic frequencies (p < 0.01). These findings suggested the ATBF1-12bp deletion mutation was significantly associated with reproduction-related trait, suggesting that this deletion could be used as an effective molecular marker for litter size in goat breeding.
Related Concept Videos
Genome Size and the Evolution of New Genes
Genome Size and the Evolution of New Genes
Mutation, Gene Flow, and Genetic Drift
Mutations
Mutations
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Viral Mutations

