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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.8K

Statins and antiplatelet agents are associated with changes in the circulatory markers of endothelial dysfunction in

Estefanya García-Menéndez1, María Marques Vidas2, Matilde Alique3

  • 1Servicio de Nefrología, Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, España.

Nefrologia
|February 9, 2019
PubMed

Insights

Statins and antiplatelet agents reduce endothelial microvesicles and VEGF in chronic kidney disease (CKD) patients, normalizing levels seen in healthy individuals. This effect is independent of cholesterol, suggesting broader therapeutic benefits in CKD cardiovascular risk.

Area of Science:

  • Nephrology
  • Cardiology
  • Vascular Biology

Background:

  • Chronic kidney disease (CKD) patients face elevated cardiovascular disease (CVD) risk.
  • Mechanisms of endothelial damage and drug effects in CKD require further elucidation.
  • Endothelial dysfunction is a key factor in CKD-related CVD.

Purpose of the Study:

  • To investigate the impact of statins and antiplatelet agents (PA) on endothelial microvesicles (EMVs) and other endothelial dysfunction markers in CKD patients.
  • To analyze the correlation between therapeutic strategies and endothelial dysfunction markers.

Main Methods:

  • Cross-sectional study involving 41 patients with CKD (stages 3b-4) and 8 healthy volunteers.
  • Quantification of circulating EMVs, vascular endothelial growth factor (VEGF), and advanced oxidized protein products (AOPPS).
  • Evaluation of correlations with comorbidities and treatments.

Main Results:

  • EMVs were significantly elevated in CKD patients compared to controls (171.1 vs. 68.3/μl, P<.001).
  • Statins and PA treatment correlated with reduced EMVs and VEGF levels, irrespective of serum total cholesterol (TC).
  • AOPPS and VEGF levels did not differ between CKD patients and controls.

Conclusions:

  • CKD is associated with altered EMVs, VEGF, and AOPP levels.
  • Statins and PA normalize these markers in CKD patients, resembling levels in healthy controls.
  • The observed normalization suggests pleiotropic effects of statins and PA, warranting further investigation in managing CKD-related cardiovascular risk.
Abstract

Keywords:
Antiagregantes plaquetariosAntiplatelet agentsChronic kidney diseaseDisfunción endotelialEndothelial dysfunctionEndothelial microvesiclesEstatinasInsuficiencia renal crónicaMicrovesículas endotelialesStatins

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