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Pre-Vent: the prematurity-related ventilatory control study

Phyllis A Dennery1, Juliann M Di Fiore2, Namasivayam Ambalavanan3

  • 1Hasbro Children's Hospital, Warren Alpert School of Medicine, Brown University, Providence, RI, USA. phyllis_dennery@brown.edu.

Pediatric Research
|February 9, 2019
PubMed

Insights

This study analyzes cardiorespiratory data in preterm infants to understand immature ventilatory control and identify markers for bronchopulmonary dysplasia, aiming for better respiratory outcomes.

Area of Science:

  • Neonatal Medicine
  • Respiratory Physiology
  • Pediatric Critical Care

Background:

  • Bronchopulmonary dysplasia (BPD) incidence is rising in premature infants, potentially linked to immature ventilatory control and hypoxemia.
  • Current treatments for hypoxemia carry risks of adverse sequelae.
  • The Prematurity-Related Ventilatory Control Study seeks to address these issues.

Purpose of the Study:

  • To analyze continuous cardiorespiratory waveform data in preterm infants.
  • To delineate mechanisms of immature ventilatory control.
  • To identify predictive markers for adverse respiratory outcomes.

Main Methods:

  • Collecting continuous ECG, heart rate, respiratory, and oxygen saturation data in 500 preterm infants (<29 weeks gestation) across 5 centers.
  • Assessing mild permissive hypercapnia, hyperoxia, and hypoxia in a subcohort.
  • Gathering inpatient questionnaires, urine, serum, and DNA samples.

Main Results:

  • Primary outcomes include respiratory status at 40 weeks and quantitative measures of immature breathing.
  • Physiologic and biologic determinants will be collected to refine predictive models.
  • Linking ventilatory control mechanisms to infant respiratory outcomes.

Conclusions:

  • Elucidating individualized cardiopulmonary phenotypes in premature infants.
  • Understanding mechanisms of ventilatory control contributing to adverse respiratory outcomes.
  • Incorporating bedside monitoring and biomarkers to predict respiratory outcomes.
Abstract

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