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Updated: Jan 29, 2026

Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells
Published on: May 5, 2023
Current and future options for dental pulp therapy
Takahiko Morotomi1, Ayako Washio1, Chiaki Kitamura1
1Division of Endodontics and Restorative Dentistry, Department of Science of Oral Functions, Kyushu Dental University, 2-6-1 Manazuru, Kokurakita-ku, Kitakyushu 803-8580, Japan.
Dental pulp therapies are evolving with new biomaterials and stem cell research. This review covers current and future options for pulp preservation and regeneration, aiming to improve tooth health and patient quality of life.
Area of Science:
- Biomaterials Science
- Dental Research
- Regenerative Medicine
Background:
- Dental pulp, a vital connective tissue, performs crucial functions but is vulnerable to damage due to its low compliance within hard tooth structures.
- Damage, such as from dental caries, often necessitates pulp removal, leading to tooth fragility and reduced quality of life.
Purpose of the Study:
- To review current and future therapeutic strategies for dental pulp preservation and regeneration.
- To discuss advancements in biomaterials and pulp biology relevant to endodontic treatments.
Main Methods:
- Literature review of current and emerging dental pulp therapies.
- Categorization of treatments into direct pulp capping, vital pulp amputation, and non-vital tooth management.
Main Results:
- Advancements in bioceramics and dental pulp stem cell research are driving novel approaches.
- Emerging therapies focus on pulp preservation and regeneration rather than complete removal.
Conclusions:
- Novel biomaterials and regenerative approaches offer promising future directions for dental pulp treatment.
- Optimizing therapies for direct pulp capping, vital pulp amputation, and non-vital teeth is crucial for preserving tooth structure and enhancing patient outcomes.
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