Structure Ligation Relationship of Amino Acids for the Amination Cross-Coupling Reactions
Gargi Nikhil Vaidya1, Arif Khan1, Hansa Verma1
1Department of Medicinal Chemistry , National Institute of Pharmaceutical Education and Research (NIPER) - Ahmadabad , Palaj, Gandhinagar 382355 , Gujarat , India.
Abstract:
The structure ligation relationship (SLR) of amino acids (AAs) for the cross-coupling aminations was examined. While AA ligated C-N cross-couplings under Pd and Ni catalysis were minor or ineffective, the AA ligated Cu-catalyzed C-N cross-couplings were promising particularly with the use of l-methionine. The roles of -NH2, -CO2H, and -S- of l-methionine were investigated and found critical for their ligation efficiency. The finding was compatible with aromatic as well as aliphatic amines including tautomerizable N-heteroarenes.
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