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Role of transient receptor potential channels in adipocyte biology

Mahendra Bishnoi1,2, Kanthi K Kondepudi1, Ritesh K Baboota1

  • 1a National Agri-Food Biotechnology Institute (NABI), C-127, Industrial Area, Phase VIII, SAS Nagar, Punjab 160071, India.

Expert Review of Endocrinology & Metabolism
|February 10, 2019
PubMed

Insights

Transient Receptor Potential (TRP) channels are crucial in calcium signaling and have roles in obesity. This review explores TRP channel involvement in adipocyte biology and their potential as therapeutic targets for obesity management.

Area of Science:

  • Physiology
  • Molecular Biology
  • Pharmacology

Background:

  • Transient Receptor Potential (TRP) channels are a superfamily of 28 nonselective cation channels permeable to calcium.
  • TRP channels, particularly TRPV1, TRPA1, and TRPM8, are established players in nociception.
  • Emerging evidence highlights TRP channel presence and function in diverse tissues, including the bladder, skin, respiratory system, and brain.

Purpose of the Study:

  • To review the involvement of TRP channels in adipocyte differentiation and their role in obesity.
  • To explore the potential significance of TRP channels in adipocyte biology, considering their calcium permeability and the role of calcium signaling in adipogenesis.
  • To evaluate TRP channels as potential therapeutic targets for obesity management.

Main Methods:

  • Literature review of studies investigating TRP channels in adipogenesis, obesity, and related complications.
  • Analysis of existing research on TRP channel expression and function in various tissues relevant to metabolic health.
  • Synthesis of data linking calcium signaling via TRP channels to adipocyte biology.

Main Results:

  • TRP channels play a significant role in adipocyte differentiation and function.
  • Dysregulation of TRP channels is implicated in the pathogenesis of obesity and its associated complications.
  • Specific TRP channels (TRPV1, TRPA1, TRPM8) show particular relevance in the context of metabolic health.

Conclusions:

  • TRP channels are integral to adipocyte biology and metabolic regulation.
  • Targeting TRP channels offers a promising therapeutic strategy for combating obesity.
  • Further research into TRP channel modulators could lead to novel obesity treatments.
Keywords:
adipogenesiscalciumcapsaicindietary constituentsobesitytransient receptor potential channels

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