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A Millimeter Scale Flexural Testing System for Measuring the Mechanical Properties of Marine Sponge Spicules
Published on: October 11, 2017
New Acyclic Cytotoxic Jasplakinolide Derivative from the Marine Sponge Jaspis splendens
Sherif S Ebada1,2,3, Werner E G Müller4, Wenhan Lin5
1Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, Universitaetsstrasse 1, D-40225 Duesseldorf, Germany. sherif_elsayed@pharma.asu.edu.eg.
Abstract:
A new acylic jasplakinolide congener (2), another acyclic derivative requiring revision (4), together with two jasplakinolide derivatives including the parent compound jasplakinolide (1) were isolated from the Indonesian marine sponge Jaspis splendens. The chemical structures of the new and known compounds were unambiguously elucidated based on HRESIMS and exhaustive 1D and 2D NMR spectral analysis as well as a comparison of their NMR data with those of jasplakinolide (1). The isolated jasplakinolides inhibited the growth of mouse lymphoma (L5178Y) cells in vitro with IC50 values in the low micromolar to nanomolar range.
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Measurement: Derived Units
Higher Derivatives
Derivatives
The Derivative as a Function

