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Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

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Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
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Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
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Restless Leg Syndrome and Night Terrors01:27

Restless Leg Syndrome and Night Terrors

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Restless Leg Syndrome (RLS), also known as Willis-Ekbom disease, is a neurological disorder characterized by an uncontrollable urge to move the legs due to uncomfortable sensations. These sensations typically occur during periods of rest or inactivity, particularly when lying down or sitting, and can severely disrupt sleep.
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
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Acute Coronary Syndrome V: Nursing Management01:26

Acute Coronary Syndrome V: Nursing Management

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Nursing Assessment:Nursing management of acute coronary syndrome (ACS) involves taking the patient's history, focusing on primary complaints such as chest pain, dyspnea, and excessive sweating (diaphoresis), as well as other symptoms like back or jaw pain, nausea, vomiting, palpitations, dizziness, and fatigue. The nurse also reviews the patient's history of cardiac events, risk factors such as hypertension, diabetes, smoking, family history, and current medications.In the objective assessment,...
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Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

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IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
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Dual-mode Imaging of Cutaneous Tissue Oxygenation and Vascular Function
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Cutaneous paraneoplastic syndromes.

Mark R Wick1, James W Patterson1

  • 1PRW Laboratories, Charlottesville, VA, United State.

Seminars in Diagnostic Pathology
|February 10, 2019
PubMed
Summary
This summary is machine-generated.

Paraneoplastic skin disorders are markers of underlying malignant diseases. This review categorizes these skin conditions by their associated cancer type, aiding in diagnosis.

Keywords:
Non-neoplastic disorders in cancer patientsParaneoplastic conditionsSkin diseases accompanying malignancies

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Cutaneous abnormalities in cancer patients can be infectious, directly invasive, or paraneoplastic.
  • Paraneoplastic skin lesions serve as crucial markers for underlying malignancies.

Purpose of the Study:

  • To review and categorize paraneoplastic skin disorders.
  • To group these conditions based on their associated malignancy type.

Main Methods:

  • Literature review and synthesis of existing data on paraneoplastic dermatoses.
  • Classification of skin lesions according to associated cancer types (alimentary, hematolymphoid, diverse).

Main Results:

  • Paraneoplastic syndromes are associated with alimentary tract malignancies (e.g., acanthosis nigricans, necrolytic migratory erythema).
  • Hematolymphoid malignancies are linked to conditions like pemphigus paraneoplastica and Sweet syndrome.
  • Diverse malignancies can present with paraneoplastic skin findings such as dermatomyositis and erythema gyratum repens.

Conclusions:

  • Recognizing paraneoplastic skin disorders is vital for identifying underlying cancers.
  • Pathologists play a key role in diagnosing these conditions, aiding in cancer characterization.