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Updated: Jan 29, 2026

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
Published on: September 21, 2011
Review of fluorescent steroidal ligands for the estrogen receptor 1995-2018
Nisal Gajadeera1, Robert N Hanson1
1Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston MA02115-5000, United States.
Abstract:
The development of fluorescent ligands for the estrogen receptor (ER) continues to be of interest. Over the past 20 years, most efforts have focused on appending an expanding variety of fluorophores to the B-, C- and D-rings of the steroidal scaffold. This review highlights the synthesis and evaluation of derivatives substituted primarily at the 6-, 7α- and 17α-positions, culminating with our recent work on 11β-substituted estradiols, and proposes an approach to new fluorescent imaging agents that retain high ER affinity.
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