Related Experiment Video
Updated: Jan 29, 2026

In vivo Assessment of Microtubule Dynamics and Orientation in Caenorhabditis elegans Neurons
Published on: November 20, 2021
Microtubule control of functional architecture in neurons
Michael T Kelliher1, Harriet Aj Saunders1, Jill Wildonger2
1Integrated Program in Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA; Biochemistry Department, University of Wisconsin-Madison, Madison, WI 53706, USA.
Abstract:
Neurons are exquisitely polarized cells whose structure and function relies on microtubules. Microtubules in signal-receiving dendrites and signal-sending axons differ in their organization and microtubule-associated proteins. These differences, coupled with microtubule post-translational modifications, combine to locally regulate intracellular transport, morphology, and function. Recent discoveries provide new insight into the regulation of non-centrosomal microtubule arrays in neurons, the relationship between microtubule acetylation and mechanosensation, and the spatial patterning of microtubules that regulates motor activity and cargo delivery in axons and dendrites. Together, these new studies bring us closer to understanding how microtubule function is locally tuned to match the specialized tasks associated with signal reception and transmission.
More Related Videos
Related Concept Videos
Microtubules
Microtubules
Microtubules have two structurally similar globular protein subunits: α and β tubulins. In the cytosol, the α and β tubulins form a heterodimer....
Transfer Function in Control Systems
To derive the transfer function, consider a general nth-order linear time-invariant...
Structural Protein Function
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to...
Microtubule Instability
Microtubule Formation

