The threshold detectable mass diameter for 2D-mammography and digital breast tomosynthesis
Andria Hadjipanteli1, Premkumar Elangovan2, Alistair Mackenzie2
1National Coordinating Centre for the Physics of Mammography, Royal Surrey County Hospital, Guildford, Surrey, UK; Medical School, University of Cyprus, Nicosia, Cyprus.
Summary
Digital breast tomosynthesis (DBT) significantly improves lesion detection compared to 2D-mammography. Both narrow and wide-angle DBT show superior performance in identifying smaller masses, crucial for early breast cancer screening.
Area of Science:
- Radiology
- Medical Imaging
- Oncology
Background:
- Digital breast tomosynthesis (DBT) is being evaluated for integration into national breast screening programs.
- DBT offers potential advantages over traditional 2D-mammography for breast cancer detection.
Purpose of the Study:
- To compare the threshold detectable mass diameters for narrow-angle and wide-angle DBT against 2D-mammography.
- To assess the efficacy of different DBT configurations in simulated breast tissue.
Main Methods:
- Simulated 60mm compressed breasts with and without masses were used.
- Image modeling tools for 2D-mammography and DBT were employed.
- 4-alternative forced choice (4AFC) experiments assessed signal detection.
Main Results:
- Threshold detectable mass diameters for 2D-mammography (10.2 ± 1.4 mm) were significantly larger than for narrow-angle DBT (6.0 ± 1.1 mm) and wide-angle DBT (5.6 ± 1.2 mm).
- No significant difference was observed between narrow and wide-angle DBT performance.
- All DBT modalities achieved this at a mean glandular dose of 2.5 mGy.
Conclusions:
- DBT, both narrow and wide-angle, demonstrates superior detection of smaller masses compared to 2D-mammography.
- These findings support the potential introduction of DBT, alone or combined with 2D-mammography, in breast cancer screening programs.
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