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Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
Published on: July 28, 2023
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Correlation between Serum 25-Hydroxyvitamin D Levels with Keloid Severity.
Vira Indhiratamin Damanik1, Imam Budi Putra2,3, Oratna Ginting2,3
1Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Open Access Macedonian Journal of Medical Sciences
|February 12, 2019
Summary
Lower vitamin D levels correlate with increased keloid severity. This study found a significant negative correlation between serum 25-hydroxyvitamin D and keloid severity, suggesting vitamin D
Area of Science:
- Dermatology and Endocrinology
- Biochemistry and Molecular Biology
Background:
- Keloids are characterized by excessive extracellular matrix deposition.
- Vitamin D inhibits keloid fibroblast proliferation and extracellular matrix production.
- Vitamin D derivatives show potential as preventive keloid treatments.
Purpose of the Study:
- To investigate the relationship between serum 25-hydroxyvitamin D levels and keloid severity.
- To assess the correlation between vitamin D status and keloid clinical presentation.
Main Methods:
- Cross-sectional study of 32 keloid patients.
- Keloid diagnosis via history and clinical examination.
- Severity assessment using the Vancouver Scar Scale (VSS).
- Measurement of serum 25-hydroxyvitamin D levels.
Main Results:
- A significant negative correlation was observed between serum 25-hydroxyvitamin D levels and keloid severity (p = 0.0001, r = -0.737).
- No significant correlation was found between vitamin D levels and gender, age, keloid duration, or family history.
Conclusions:
- Lower serum 25-hydroxyvitamin D levels are associated with increased keloid severity.
- Vitamin D levels do not significantly correlate with demographic or historical factors in keloid patients.
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