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Electrophysiology of Scorpion Peg Sensilla
Published on: April 13, 2011
PEGylation of therapeutic oligonucletides: From linear to highly branched PEG architectures
1Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, USA.
Abstract:
PEGylation, the attachment of poly(ethylene glycol) (PEG), has been adopted to improve the pharmacokinetic properties of oligonucleotide therapeutics for nearly 30 years. Prior efforts mainly focused on the investigation of linear or slightly branched PEG having different molecular weights, terminal functional groups, and possible oligonucleotide sites for functionalization. Recent studies on highly branched PEG (including brush, star, and micellar structures) indicate superior properties in several areas including cellular uptake, gene regulation efficacy, reduction of side effects, and biodistribution. This review focuses on comparing the effects of PEG architecture on the physiochemical and biological properties of the PEGylated oligonucleotide.
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