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A Novel Technique for Generating and Observing Chemiluminescence in a Biological Setting
Published on: March 9, 2017
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Recent advances in electrogenerated chemiluminescence biosensing methods for pharmaceuticals
Yu Zhang1, Rui Zhang2, Xiaolin Yang3
1Medpace Bioanalytical Laboratories, 5365 Medpace Way, Cincinnati, OH 45227, USA.
Journal of Pharmaceutical Analysis
|February 12, 2019
Summary
Electrogenerated chemiluminescence (ECL) is a powerful analytical tool. This review highlights recent molecular recognition biosensing trends for pharmaceutical analysis using ECL since 2010.
Area of Science:
- Analytical Chemistry
- Biochemistry
- Materials Science
Background:
- Electrogenerated chemiluminescence (ECL) involves light emission from species generated at electrode surfaces via electron-transfer reactions.
- ECL is a versatile analytical technique applied in clinical diagnostics, biowarfare detection, and pharmaceutical analysis.
- Molecular recognition-based biosensing is crucial for accurate and sensitive detection.
Purpose of the Study:
- To review current trends in molecular recognition-based biosensing for pharmaceutical analysis utilizing ECL since 2010.
- To provide an overview of recent advancements in various ECL-based biosensor formats.
- To discuss future perspectives in the field.
Main Methods:
- Review of scientific literature published since 2010 focusing on ECL biosensors for pharmaceutical analysis.
- Categorization of ECL biosensing methods including ECL immunoassay (ECLIA), immunosensors, enzyme-based biosensors, aptamer-based biosensors, and molecularly imprinted polymer (MIP)-based sensors.
- Analysis of trends and developments in these ECL-based techniques.
Main Results:
- Significant advancements in ECL immunoassay (ECLIA) and immunosensors for detecting pharmaceutical compounds.
- Emerging applications of enzyme-based, aptamer-based, and molecularly imprinted polymer (MIP)-based biosensors utilizing ECL.
- Demonstrated high sensitivity and specificity of ECL biosensing methods in pharmaceutical analysis.
Conclusions:
- Molecular recognition-based ECL biosensing has shown remarkable progress in pharmaceutical analysis since 2010.
- Various ECL biosensor platforms offer promising avenues for sensitive and selective drug detection.
- Continued research and development are expected to further enhance the capabilities of ECL biosensing in pharmaceutical applications.
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