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The coated wire electrode glucose sensor.

E S Wilkins1, M G Wilkins

  • 1Department of Chemical and Nuclear Engineering, Farris Engineering Center, University of New Mexico, Albuquerque.

Hormone and Metabolic Research. Supplement Series
|January 1, 1988
PubMed
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This study introduces a novel glucose-coated wire electrode for sensing glucose. The developed sensor demonstrates a linear response to glucose concentration and exhibits a rapid response time with minimal interference.

Area of Science:

  • Electrochemistry
  • Biosensors
  • Analytical Chemistry

Background:

  • Existing glucose sensing and measurement techniques are briefly reviewed.
  • The development of glucose-coated wire electrodes is rooted in liquid membrane technology.

Purpose of the Study:

  • To describe the principle and fabrication of a novel glucose-coated wire electrode.
  • To evaluate the sensor's performance, including response characteristics, time response, and lifetime.
  • To investigate potential interference effects from common biological compounds.

Main Methods:

  • Utilized a quaternary ammonium salt with a sparingly soluble metallic salt of glucose in a poly(vinyl chloride) matrix.
  • Detailed fabrication procedures for the glucose-coated wire electrode.

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  • Employed liquid Nuclear Magnetic Resonance (NMR) for mechanistic studies and tested interference effects with ascorbic acid, uric acid, L-cystine, glycine, and bilirubin.

    • Main Results:

    • The sensor exhibits a voltage that decreases linearly with increasing glucose concentration from approximately 40 mg/dl to 200 mg/dl.
    • The sensor demonstrates a rapid time response, on the order of seconds.
    • Observed sensor lifetime is on the order of several months, with no significant interference effects from tested compounds.

    Conclusions:

    • The glucose-coated wire electrode offers a promising new method for glucose sensing.
    • The sensor provides a reliable and selective measurement of glucose concentration within a clinically relevant range.
    • The developed electrode technology shows potential for long-term glucose monitoring applications.