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TRAIL pathway targeting therapeutics
Marie D Ralff1,2, Wafik S El-Deiry2
1MD/PhD Program, Lewis Katz School of Medicine, Temple University, Philadelphia, PA.
Expert Review of Precision Medicine and Drug Development
|February 12, 2019
Summary
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) therapy shows promise for cancer treatment. Novel strategies and combination therapies are being explored to overcome resistance and enhance TRAIL
Area of Science:
- Oncology
- Molecular Biology
- Immunology
Background:
- Cancer remains a major global health challenge despite extensive research.
- Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) selectively induces cancer cell death, sparing normal cells.
Purpose of the Study:
- To review current TRAIL therapy (TRAIL receptor agonists - TRAs) and strategies to improve efficacy.
- To explore unconventional TRAIL pathway activation methods, including small molecules.
- To discuss TRAIL resistance mechanisms and combination strategies to overcome them.
Main Methods:
- Review of existing literature on TRAIL therapy and related research.
- Analysis of strategies to enhance TRAIL efficacy.
- Examination of mechanisms of resistance and combination approaches.
Main Results:
- Initial TRAIL receptor agonist (TRA) clinical trials faced limitations.
- Novel approaches and TRAIL-inducing small molecules offer new therapeutic avenues.
- Combination strategies are crucial for overcoming TRAIL resistance.
Conclusions:
- Targeting the TRAIL pathway holds significant potential in oncology.
- Overcoming resistance through novel strategies and combinations is key for future TRAIL-based therapies.
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