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MicroRNAs01:22

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
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Suppose a positive test charge moves away from a positive static charge, then the Coulomb force does positive work, and its electric potential energy decreases. The potential energy per unit charge is defined as the electric potential. The electric potential is independent of the test charge.
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Difference from Background: Limit of Detection01:05

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The limit of detection (LOD) is the smallest amount of analyte that can be distinguished from the background noise. The LOD value corresponds to the concentration at which the analyte signal is three times larger than the standard deviation of the blank signal. Below this value, the analyte signal cannot be differentiated from the background noise. It is calculated by dividing the calibration slope by 3 times the standard deviation of the blank signals.
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Updated: Jan 29, 2026

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy
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MicroRNA Profile Differences in Neonates at Risk for Cerebral Palsy.

S D Chapman1, L Farina2, K Kronforst3

  • 1United States Naval Hospital Okinawa, 18 Medical Group, Kadena Air Base, Okinawa, Japan.

Physical Medicine and Rehabilitation International
|February 12, 2019
PubMed
Summary
This summary is machine-generated.

Plasma microRNA profiles in at-risk neonates differ based on cerebral palsy risk factors like abnormal tone and intraventricular hemorrhage, showing potential for early CP prediction.

Keywords:
BiomarkersCerebral palsyMicroRNAs

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Area of Science:

  • Neonatal research
  • Biomarker discovery
  • Genomics

Background:

  • Cerebral palsy (CP) diagnosis is delayed until 18-24 months.
  • Biomarkers are needed for early CP prediction and therapy assessment.
  • MicroRNAs (miRs) are established disease biomarkers.

Purpose of the Study:

  • To investigate if plasma miR profiles differ in neonates with CP risk factors.
  • To identify potential miR biomarkers for CP prediction.

Main Methods:

  • Cohort study of 31 high-risk neonates (<32 weeks gestation, <1500g).
  • Plasma samples analyzed using locked nucleic acid quantitative real-time PCR (qRT-PCR).
  • miR profiles compared based on presence/absence of intraventricular hemorrhage (IVH) and abnormal tone.

Main Results:

  • Significant differences in plasma miR profiles were observed between neonates with and without IVH.
  • Distinct miR profiles were found in neonates with and without abnormal tone.
  • Greater differences in miR profiles were noted in the abnormal tone comparison versus the IVH comparison.

Conclusions:

  • Plasma miR profiles demonstrate potential as predictive biomarkers for cerebral palsy.
  • This study identified potential miR candidates for future research in CP.