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Updated: Jan 29, 2026

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
Published on: July 27, 2022
Nano-silver hydroxyapatite based antibacterial 3D scaffolds of gelatin/alginate/poly (vinyl alcohol) for bone tissue
Rajesh Kumar Saini1, Laxami Prasad Bagri1, A K Bajpai1
1Bose Memorial Research Laboratory, Government Model Science College, Jabalpur, M.P., 482001, India.
Abstract:
In the present study macroporous three dimensional spongy scaffolds composed of gelatin, alginate, and poly (vinyl alcohol) were prepared by cryogelation technique and silver hydroxyapatite was reinforced into the 3 D matrix. The polymer nanocomposite materials were characterized by analytical techniques such as Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and x-ray diffraction (XRD) analysis. The nanocomposite scaffolds were studied for their porous nature, water sorption capacity, and mechanical behavior. The suitability of scaffolds for bone tissue engineering applications was judged by evaluating their antibacterial and cytotoxic nature against gram positive and gram negative bacteria, and MC3T3-E1 preosteoblast cells, respectively. The scaffolds were also studied for release of silver ions and the influence of various experimental conditions on the release profiles of silver ions was investigated.
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