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Updated: Jan 29, 2026

Duodenal-Jejunal Bypass Surgery in Diet-Induced Obese Diabetic Mice
Published on: October 18, 2024
Targeting the intestinal L-cell for obesity and type 2 diabetes treatment
Nicolai Jacob Wewer Albrechtsen1, Rune Ehrenreich Kuhre1, Carolyn F Deacon1
1a Faculty of Health and Medical Sciences, NNF Center for Basic Metabolic Research, Section for Translational Metabolism, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.
Abstract:
Degradation-resistant glucagon-like peptide-1 (GLP-1) mimetics and GLP-1 enhancers (inhibitors of dipeptidyl peptidase-4, the enzyme which degrades and inactivates GLP-1) have been used for treatment of type 2 diabetes mellitus since 2005-2006. Cutting-edge research is now focusing on uncovering the secretory mechanisms of the GLP-1-producing cells (L-cells) with the purpose of developing agonists that enhance endogenous hormone secretion. Since GLP-1 co-localizes with other anorectic peptides, cholecystokinin, oxyntomodulin/glicentin and peptide YY, L-cell targeting might cause release of several hormones at the same time, providing additive effects on appetite and glucose regulation. In this review, we explore the role of proglucagon-derived peptides and other L-cell co-localizing hormones, in appetite regulation and the mechanism regulating their secretion.
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