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The Relationship between Platelet Count and Host Gut Microbiota: A Population-Based Retrospective Cross-Sectional
Hee-Young Yoon1, Han-Na Kim2, Su Hwan Lee3
1Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul 07804, Korea. bluecat-s@hanmail.net.
Journal of Clinical Medicine
|February 13, 2019
Summary
Higher platelet counts correlate with reduced gut microbial diversity and lower levels of beneficial bacteria like Faecalibacterium. This suggests even normal platelet variations impact gut health.
Area of Science:
- Microbiology
- Hematology
- Human Health
Background:
- Platelet count is a key indicator for disease severity and prognosis.
- Gut microbiota alterations are associated with various chronic diseases.
Purpose of the Study:
- To investigate the association between gut microbiota composition and platelet count.
- To explore how platelet levels influence gut microbial diversity and abundance.
Main Methods:
- Analysis of fecal 16S RNA gene sequencing data from 1268 subjects.
- Comparison of gut microbiota between subjects in the upper quartile of platelet count and the lower three quartiles.
- Assessment of alpha and beta diversity metrics and relative abundance of bacterial genera.
Main Results:
- Subjects with higher platelet counts exhibited significantly lower alpha diversity (observed amplicon sequence variants, phylogenetic index) and altered beta diversity (weighted UniFrac, Jaccard dissimilarity).
- The upper quartile platelet group showed decreased relative abundance of the genus Faecalibacterium, including F. prausnitzii, which was inversely correlated with platelet count.
Conclusions:
- Increased platelet count, even within the normal range, is associated with reduced gut microbial diversity.
- Lower abundance of beneficial bacteria, particularly Faecalibacterium, is linked to higher platelet counts, suggesting a potential adverse impact on gut microbial composition.
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