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Updated: Jan 29, 2026

Preparation of Mitochondria from Ovarian Cancer Tissues and Control Ovarian Tissues for Quantitative Proteomics Analysis
Published on: November 18, 2019
Can complete blood count inflammatory parameters in epithelial ovarian cancer contribute to prognosis? - a survival
Mehmet Ufuk Ceran1, Umit Tasdemir2, Eser Colak2
1Department of Gynecology and Obstetrics, Baskent University School of Medicine, Konya Medical and Research Center, Selcuklu, Konya, Turkey. mehmet.ufuk.ceran@gmail.com.
Subjective:
The aim of the present study was to investigate the prognostic significance of preoperative complete blood count inflammatory markers in women operated for invasive Epithelial Ovarian Cancer (EOC).
Method:
Two hundred forty four patients that underwent operation with the diagnosis of invasive EOC between 2006 and 2014 were included in the study. The date of operation, date of recurrence and final mortality evaluations were performed for survival analysis. The sensitivity, specificity, PPV and NPV were separately calculated with ROC analysis. Survival analysis was carried out with Kaplan Meier-Log Rank Method.
Results:
Five-years overall survival rate was 56, 9% and 5-year disease-free survival (DFS) rate was 45,5%. Advanced disease stage, moderate-poor tumor differentiation, and the presence of recurrence were determined to have significant inverse relation at mean survival and 5-year survival rates. Neutrophil/lymphocyte ratio (NLR) and Platelet lymphocyte ratio (PLR) had prognostic effect on both DFS and overall survival based upon the cut-off values determined in the study (PLR = 231, s36, NLR = 3,83). Histopathological subtypes were not found to have any prognostic value. In correlation analysis, PLR and NLR had positive correlation with each other and negative correlation with overall survival.
Conclusions:
Inflammatory markers such as NLR and PLR have independent prognostic value for women who undergo surgery for invasive EOC.
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