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Serum S100B levels in patients with depression.

Parul Arora1, Rajesh Sagar2, Manju Mehta2

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Indian Journal of Psychiatry
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Serum S100B levels are elevated in individuals with major depression, particularly in females and those with recurrent episodes. This protein may serve as a valuable biomarker for diagnosing depression.

Keywords:
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Area of Science:

  • Neuroscience
  • Biochemistry
  • Psychiatry

Background:

  • The blood-brain barrier (BBB) regulates brain entry of peripheral components, and its integrity is crucial in neurological disorders.
  • S100B protein is linked to BBB damage and has been observed at higher levels in depressed individuals' serum and cerebrospinal fluid.

Purpose of the Study:

  • To investigate serum S100B levels as a potential biomarker for depression.
  • To explore correlations between S100B levels and depression severity, episode type, and treatment duration.

Main Methods:

  • Recruited 42 depressed patients (13-25 years) and 42 healthy controls.
  • Assessed depression severity using Beck's Depression Inventory-II and Hamilton Depression Rating Scale.
  • Measured serum S100B levels via Sandwich ELISA and performed statistical analysis.

Main Results:

  • Serum S100B levels were significantly higher in depressed patients compared to controls.
  • Elevated S100B was notably observed in depressed females and those with recurrent depression.
  • Higher S100B levels correlated with longer illness duration under antidepressant treatment, but not clinical severity.

Conclusions:

  • Serum S100B demonstrates potential as a reliable biomarker for depression.
  • S100B levels may offer insights into specific patient subgroups and illness progression.