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Calcium and the inner ear fluids.

E Ferrary1, P Tran Ba Huy, N Roinel

  • 1Department de Physiologie, Faculté Xavier Bichat, Université Paris 7, France.

Acta Oto-Laryngologica. Supplementum
|January 1, 1988
PubMed
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This study measured total and ionized calcium in inner ear fluids. Findings suggest calcium actively enters endolymph, potentially as undissociated salts, influencing hearing function.

Area of Science:

  • Oto-rhino-laryngology
  • Neuroscience
  • Biochemistry

Background:

  • Calcium ions (Ca) are crucial for inner ear function, including auditory transduction.
  • Understanding Ca distribution in inner ear fluids is vital for diagnosing and treating hearing disorders.

Purpose of the Study:

  • To quantify total and ionized calcium concentrations in perilymph and endolymph.
  • To investigate the relationship between endocochlear potential and ionized Ca fraction.
  • To elucidate the transport mechanism of Ca across the perilymph-endolymph barrier.

Main Methods:

  • Total Ca determined using fluorimetry, spectrophotometry, and electron probe analysis.
  • Ionized Ca measured with selective microelectrodes.
  • Electrochemical potential gradients analyzed.

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Main Results:

  • Perilymph total Ca (1.2 mM) and ionized fraction (80%) resemble plasma.
  • Endolymph exhibits lower total Ca (0.5 mM) and significantly lower ionized Ca (0.02 mM).
  • Reduced endocochlear potential increased the ionized Ca fraction in endolymph.

Conclusions:

  • Most endolymphatic Ca may exist as undissociated salts (e.g., bicarbonate, phosphate).
  • Active calcium transport into endolymph is implied by electrochemical gradients.
  • These findings offer insights into the physiological mechanisms of hearing.