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WITHDRAWN: MicroRNA-125b can Target p38MAPK to Resolve Intermittent Hypoxia- Induced Dementia in Murine Models

Haiyan Ren1, Weibin Qiu2, Chen Peng1

  • 1Department of Neurology, Shanghai Eighth People's Hospital, Shanghai. China.

Current Neurovascular Research
|February 13, 2019
PubMed

Insights

This study investigated how microRNA-125b affects dementia caused by intermittent hypoxia in mice. The research aimed to understand the molecular mechanisms involving p38MAPK signaling.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Intermittent hypoxia is linked to cognitive decline and dementia.
  • MicroRNAs play crucial roles in regulating gene expression and cellular processes.
  • p38MAPK signaling pathway is implicated in various neurological disorders.

Purpose of the Study:

  • To explore the therapeutic potential of microRNA-125b in mitigating dementia.
  • To elucidate the role of microRNA-125b in targeting p38MAPK.
  • To investigate the effects of intermittent hypoxia on cognitive function in murine models.

Main Methods:

  • Murine models were subjected to intermittent hypoxia.
  • MicroRNA-125b levels and p38MAPK activity were analyzed.
  • Cognitive functions were assessed using behavioral tests.
  • Molecular mechanisms were investigated using biochemical assays.

Main Results:

  • MicroRNA-125b was found to target p38MAPK.
  • Modulation of microRNA-125b affected p38MAPK activity.
  • Intermittent hypoxia induced dementia-like symptoms in murine models.
  • MicroRNA-125b showed potential in resolving these symptoms.

Conclusions:

  • MicroRNA-125b may serve as a therapeutic target for dementia.
  • Targeting p38MAPK via microRNA-125b could be a strategy to treat hypoxia-induced cognitive impairment.
  • Further research is warranted to validate these findings in clinical settings.

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