Related Experiment Video
Updated: Jan 29, 2026

A System for Tracking the Dynamics of Social Preference Behavior in Small Rodents
Published on: November 21, 2019
Tracking oxytocin functions in the rodent brain during the last 30 years: From push-pull perfusion to chemogenetic
Inga D Neumann1, Rainer Landgraf2
1Department of Behavioural and Molecular Neurobiology, Regensburg Centre of Neurosciences, University of Regensburg, Regensburg, Germany.
Abstract:
A short overview is provided of the last 30 years of oxytocin (and vasopressin) research performed in our laboratories, starting with attempts to monitor the release of this nonapeptide in the rodent brain during physiological conditions such as suckling in the lactating animal. Using push-pull perfusion and microdialysis approaches, release patterns in hypothalamic and limbic brain regions could be characterised to occur from intact neuronal structures, to be independent of peripheral secretion into blood, and to respond differentially to various stimuli, particularly those related to reproduction and stress. Parallel efforts focused on the functional impact of central oxytocin release, including neuroendocrine and behavioural effects mediated by nonapeptide receptor interactions and subsequent intraneuronal signalling cascades. The use of a variety of sophisticated behavioural paradigms to manipulate central oxytocin release, along with pharmacological, genetic and pharmacogenetic approaches, revealed multiple consequences on social behaviours, particularly social fear.
Related Concept Videos
Drive-Reduction Theory: Push Theory of Motivation
Functional Brain Systems: Limbic System
Higher Mental Functions of the Brain: Language
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
Higher Mental Functions of Brain: Learning and Memory
Incentive Theory: Pull Theory of Motivation
The theory differentiates between...
Functional Brain Systems: Reticular Formation
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...

