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Comparison between Glyceryl Trinitrate and Trimetazidine in Ischaemic Cardiomyopathy Patients

M H Hoque1, F I Kabir, J Arzu

  • 1Dr Md Harisul Hoque, Professor, Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.

Mymensingh Medical Journal : MMJ
|February 14, 2019
PubMed

Insights

Glyceryl trinitrate (GTN) is a more effective and cheaper treatment for relieving angina in ischaemic cardiomyopathy (ICM) patients than trimetazidine (TMZ). GTN showed statistically significant symptom improvement at 6 and 12 weeks.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Ischaemic cardiomyopathy (ICM) significantly contributes to morbidity and mortality globally.
  • Effective management of ICM hinges on addressing anginal symptoms and assessing myocardial status.
  • Glyceryl trinitrate (GTN) and trimetazidine (TMZ) are common anti-anginal medications.

Purpose of the Study:

  • To compare the efficacy of GTN versus TMZ in treating angina in ICM patients.
  • To clarify confusions regarding the use of GTN and TMZ in ICM management.
  • To provide evidence for precise clinical decision-making in ICM treatment.

Main Methods:

  • A prospective pilot study involving ICM patients admitted to BSMMU, Dhaka, Bangladesh.
  • Patients were randomized into two groups, one receiving GTN and the other TMZ.
  • Symptom assessment using NYHA and CCS classes at baseline, discharge, 6 weeks, and 12 weeks.

Main Results:

  • No significant difference in NYHA and CCS class at baseline and discharge between GTN and TMZ groups.
  • GTN group demonstrated statistically significant improvement in symptoms at 6 and 12 weeks compared to the TMZ group (p<0.05).
  • GTN was observed to be a more cost-effective treatment option than TMZ.

Conclusions:

  • GTN emerged as a superior therapeutic option compared to TMZ for managing angina in ICM.
  • GTN offers a more affordable treatment alternative for ICM patients.
  • This study provides valuable insights into optimizing anti-anginal therapy in ICM.

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