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Antigen-presenting function of B lymphocytes.

S K Pierce1, J F Morris, M J Grusby

  • 1Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208.

Immunological Reviews
|December 1, 1988
PubMed
Summary
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All B cells act as antigen-presenting cells (APCs), with surface immunoglobulin (Ig) enhancing antigen presentation. Peptide-binding chaperone proteins may facilitate antigen transport and presentation on B cells for T cell recognition.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • B cells function as antigen-presenting cells (APCs).
  • Antigen presentation involves processing and surface display of peptide fragments via MHC class II molecules for T cell recognition.

Purpose of the Study:

  • To investigate B cells as APCs and the mechanisms of antigen transport and presentation.
  • To determine the roles of surface immunoglobulin (Ig) in B cell APC function.
  • To identify mechanisms involved in T cell-B cell interactions.

Main Methods:

  • Using cytochrome c as a model antigen, coupled to antibodies targeting B cell surface structures.
  • Analyzing antigen presentation by B cells using various conjugates and antisera.
  • Investigating the role of peptide-binding chaperone proteins in antigen presentation.

Related Experiment Videos

Main Results:

  • All B cells function as APCs, with no differential regulation in subpopulations.
  • Surface Ig (IgM and IgD) enhances B cell APC function by signaling and concentrating antigen for processing.
  • Antigen artificially bound to other B cell surface structures is also presented effectively.
  • A peptide-binding chaperone protein (PBP72/74) is implicated in antigen transport and presentation.
  • Activated helper T cells express a factor associated with B cell activation.

Conclusions:

  • B cells are universally capable APCs, with surface Ig playing a crucial role in augmenting antigen presentation.
  • Peptide-binding chaperone proteins likely mediate the transport and surface association of processed antigens with MHC class II molecules.
  • A T cell-derived factor may focus helper T cell function onto specific antigen-presenting B cells.