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Updated: Jan 29, 2026
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A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
Published on: March 14, 2025
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Toxic Epidermal Necrolysis and Sepsis
Daniela Dias Alves1, Nulita Lourenço2, Daniela Franco1
1Internal Medicine Department Hospital Amato Lusitano, Castelo Branco, Portugal.
European Journal of Case Reports in Internal Medicine
|February 14, 2019
Summary
This case study highlights toxic epidermal necrolysis (TEN), a severe skin reaction. Early diagnosis and immunoglobulin therapy are crucial for favorable outcomes in TEN patients.
Area of Science:
- Dermatology
- Immunology
Background:
- Toxic epidermal necrolysis (TEN) is a rare, severe mucocutaneous disease.
- It presents with widespread blistering and epidermal detachment.
- Prompt recognition and treatment are vital for patient survival.
Purpose of the Study:
- To report a case of TEN in a 63-year-old male.
- To emphasize the diagnostic features and treatment response.
Main Methods:
- Clinical observation of patient symptoms including myalgia, arthralgia, cough, and macules.
- Diagnostic procedures including Nikolsky's sign assessment and cutaneous biopsy.
- Therapeutic intervention with immunoglobulin administration.
Main Results:
- The patient presented with characteristic erythematous macules progressing to blisters.
- Cutaneous biopsy confirmed satellite cell necrosis.
- Immunoglobulin therapy led to significant improvement in skin lesions.
Conclusions:
- TEN is a critical condition requiring immediate medical attention.
- Early diagnosis and management, including immunoglobulin therapy, improve prognosis.
- This case underscores the efficacy of immunoglobulins in managing TEN.
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