Delayed Leukoencephalopathy: Three Case Reports and a Literature Review
Ángel Torralba-Morón1, Juan Ortiz-Imedio1, Montserrat Morales-Conejo1
1Internal Medicine Department, University Hospital 12 de Octubre, Madrid, Spain.
European Journal of Case Reports in Internal Medicine
|February 14, 2019
Summary
Delayed leukoencephalopathy (DL) is a rare neurological condition. This study highlights non-heroin drug use as a potential cause of DL, expanding the known spectrum of this condition.
Area of Science:
- Neurology
- Toxicology
Background:
- Delayed leukoencephalopathy (DL) is a rare neurological disorder.
- DL is typically associated with cerebral hypoxia and heroin consumption.
- This study investigates DL in the context of non-heroin drug use.
Purpose of the Study:
- To describe the clinical course of three patients with DL.
- To expand the understanding of the etiological spectrum of DL.
- To explore multifactorial causes of DL.
Main Methods:
- Case series of three DL patients admitted in 2012.
- Clinical course description.
- Review of diagnostic findings.
Main Results:
- Three cases of DL were identified.
- Non-heroin drug use was implicated as the cause.
- Clinical manifestations presented with a time lag.
Conclusions:
- Non-heroin drug use is a potential cause of DL.
- Multifactorial causes contribute to DL's clinical symptoms.
- Initial monitoring and advanced imaging are recommended for diagnosis and understanding.
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