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Updated: Jan 29, 2026
11:17
Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
Published on: October 12, 2012
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A Reflection on the Use of Enoxaparin Based on Three Case Reports
Rui Costa1, Inês Ferreira1, Ana Pedroso1
1Internal Medicine Department, Hospital São Francisco Xavier, Lisbon, Portugal.
European Journal of Case Reports in Internal Medicine
|February 14, 2019
Summary
Enoxaparin can cause serious bleeding, especially in elderly patients or those with kidney problems or extreme body weight. Careful dosing and monitoring are crucial to prevent these dangerous hemorrhagic complications.
Area of Science:
- Pharmacology
- Internal Medicine
- Clinical Case Reports
Background:
- Enoxaparin is a widely used anticoagulant for various thromboembolic conditions.
- Hemorrhagic complications are a known risk, particularly in vulnerable patient groups.
Purpose of the Study:
- To report three cases of severe abdominal hematomas associated with enoxaparin therapy.
- To highlight the importance of dose adjustment and monitoring in high-risk patients.
Main Methods:
- Case series presentation of three patients with enoxaparin-induced abdominal hematomas.
- Review of clinical presentation, diagnostic findings, and management strategies.
- Discussion of risk factors including age, renal function, and body weight.
Main Results:
- All three patients presented with sudden abdominal pain, altered consciousness, and hypotension.
- Investigations revealed acute anemia and large abdominal hematomas.
- Two patients stabilized with conservative management; one patient died.
Conclusions:
- Clinicians must be vigilant for enoxaparin-associated bleeding in high-risk individuals.
- Prompt recognition and management of hemorrhagic complications are vital for improving outcomes.
- Appropriate enoxaparin dosing, considering renal function and body weight, is essential.
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