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Pityriasis amiantacea following bone marrow transplant
1Indiana University School of Medicine, Indianapolis, USA.
Cutis
|February 14, 2019
Summary
Pityriasis amiantacea (PA), a hair disorder causing hair shaft matting, can occur after a bone marrow transplant. This case highlights PA development post-melphalan conditioning and successful treatment.
Area of Science:
- Dermatology
- Hematology
- Oncology
Background:
- Pityriasis amiantacea (PA) is a scalp condition characterized by matted hair shafts, often idiopathic.
- It can be associated with various underlying conditions and medications.
Observation:
- A 67-year-old woman with multiple myeloma developed PA post-bone marrow transplant with melphalan conditioning.
- Scalp hair changes were noted 4 weeks after transplant, progressing to multiple PA lesions over 4 months.
Findings:
- The patient's PA responded well to a management regimen including mineral oil, occlusion, and specific medicated shampoos (coal tar, salicylic acid, ketoconazole).
- The PA was potentially linked to melphalan conditioning, bone marrow transplant, or both.
Implications:
- This case suggests a possible association between bone marrow transplantation (specifically melphalan conditioning) and the development of Pityriasis amiantacea.
- Effective management strategies for PA, including topical treatments and medicated shampoos, are demonstrated.
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