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A Novel Interplay Between Irisin and PTH: From Basic Studies to Clinical Evidence in Hyperparathyroidism
Andrea Palermo1, Lorenzo Sanesi2, Graziana Colaianni2
1Unit of Endocrinology and Diabetes, Campus Bio-Medico University, Rome, Italy.
The Journal of Clinical Endocrinology and Metabolism
|February 14, 2019
Summary
Irisin levels are significantly lower in postmenopausal women with primary hyperparathyroidism (PHPT). This suggests an interplay between parathyroid hormone (PTH) and irisin metabolism, impacting bone and energy homeostasis.
Area of Science:
- Endocrinology
- Metabolic Research
- Bone Biology
Background:
- Irisin, a hormonelike molecule derived from FNDC5, influences energy homeostasis, bone status, and muscle atrophy.
- Parathyroid hormone (PTH) exerts metabolic effects that may interact with irisin's actions.
- Understanding the interplay between irisin and PTH is crucial for metabolic and bone health research.
Purpose of the Study:
- To investigate the mutual effects of irisin and PTH on their respective biological actions.
- To evaluate FNDC5 expression in response to PTH and PTH receptor expression in response to irisin.
- To compare serum irisin concentrations in postmenopausal women with and without primary hyperparathyroidism (PHPT).
Main Methods:
- In vitro studies using C2C12 myotubes treated with teriparatide (PTH analog) and MC3T3-E1 osteoblasts treated with recombinant irisin (r-irisin).
- Analysis of FNDC5 and PTH receptor mRNA and protein expression.
- A cross-sectional study comparing serum irisin levels in postmenopausal women with PHPT versus age- and BMI-matched controls.
Main Results:
- Teriparatide treatment downregulated FNDC5 expression in myotubes via Erk1/2 phosphorylation.
- Recombinant irisin significantly downregulated PTH receptor mRNA expression in osteoblasts.
- Serum irisin concentrations were significantly lower in postmenopausal women with PHPT compared to controls.
Conclusions:
- Preclinical data suggest an interaction between PTH and irisin metabolism.
- The reduced irisin levels observed in PHPT patients support the hypothesis of an interplay between these hormones.
- Further research is warranted to elucidate the clinical implications of the PTH-irisin axis in metabolic and bone diseases.
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