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Possible Association between Cathepsin V and the Development of Placenta Accreta Spectrum Disorders
Satoshi Matsukawa1, Seiji Sumigama2,3, Tomomi Kotani1
1Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Gynecologic and Obstetric Investigation
|February 14, 2019
Summary
This study investigated molecular changes in placenta accreta spectrum (PAS) disorders. Cathepsin V (CTSV) showed increased expression in the adherent site, suggesting its role in PAS pathogenesis.
Area of Science:
- Reproductive biology
- Molecular genetics
- Pathology
Background:
- Placenta accreta spectrum (PAS) disorders are characterized by abnormal trophoblast invasion.
- Understanding the molecular mechanisms of trophoblast adhesion is crucial for PAS diagnosis and treatment.
Purpose of the Study:
- To identify molecular changes associated with trophoblast adhesion in PAS.
- To evaluate the role of specific genes, such as cathepsin V (CTSV), in PAS pathogenesis.
Main Methods:
- Retrospective analysis of 10 PAS cases.
- Microarray analysis to identify upregulated genes in the trophoblast adherent site.
- Reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemistry to validate gene expression.
Main Results:
- Microarray identified 157 upregulated transcripts, including ADAM28, CTSV, CTSS, and MMP19.
- CTSV expression was significantly higher in extravillous trophoblasts (EVTs) invading the myometrium at the adherent site compared to the non-adherent site.
- MMP19 showed no difference, while ADAM28 and CTSS had weak/no staining.
Conclusions:
- CTSV may play a significant role in the pathogenesis of placenta accreta spectrum disorders.
- Further research is needed to elucidate the precise mechanisms of CTSV in PAS.
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