Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Geometric Mean01:15

Geometric Mean

4.0K
The mean is a measure of the central tendency of a data set. In some data sets, the data is inherently multiplicative, and the arithmetic mean is not useful. For example, the human population multiplies with time, and so does the credit amount of financial investment, as the interest compounds over successive time intervals.
In cases of multiplicative data, the geometric mean is used for statistical analysis. First, the product of all the elements is taken. Then, if there are n elements in the...
4.0K
Intracellular Movement of Viruses and Bacteria01:10

Intracellular Movement of Viruses and Bacteria

3.5K
Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...
3.5K
Geometric Sequences01:30

Geometric Sequences

280
In systems where values diminish by a constant proportion at each stage, the resulting sequence follows a geometric structure. Each new value in the sequence is obtained by applying a fixed multiplier to the preceding term. This regular, proportional decline type is often used to represent processes involving gradual loss, such as energy dissipation or reduction in amplitude over time.When analyzing the total effect of such a process across unlimited iterations, the series of values is referred...
280
What are Viruses?00:50

What are Viruses?

128.0K
Overview
128.0K
Chromosome Replication02:31

Chromosome Replication

10.6K
Before a cell can divide, it must accurately replicate all of its chromosomes, including the DNA and its associated histone and non-histone proteins.  This process begins at numerous origins of replication during the S phase of the cell cycle in each of a cell’s chromosomes simultaneously. Certain nucleotides can act as origins of replication, but these sequences are not well defined - especially in complex, multi-cellular, eukaryotic species. The length of DNA that spans an origin...
10.6K
DNA Replication02:40

DNA Replication

59.1K
DNA replication involves the separation of the two strands of the double helix, with each strand serving as a template from which the new complementary strand is copied.  After replication, each double-stranded DNA includes one parental or “old” strand and one “new” strand. This is known as semiconservative replication. The resulting DNA molecules have the same sequence and are divided equally into the two daughter cells.
Replication in Prokaryotes
DNA replication...
59.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Symptom burden, lung function, exercise tolerance and inflammation in patients post COVID-19: results from the prospective COVID-19 Chronic Morbidity (CCHROMO) study.

BMC pulmonary medicine·2026
Same author

Modelling human skin morphology and simulating transdermal transport of 50 chemicals.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2026
Same author

Gravitational 3D Magnetic Resonance Elastography for Differentiating Focal Nodular Hyperplasia and Hepatic Adenoma.

Diagnostics (Basel, Switzerland)·2026
Same author

Cytotoxicity of Self-Etch Versus Etch-and-Rinse Dentin Adhesives After 48 h: An In Vitro Study.

Dentistry journal·2026
Same author

Placental Histiocyte Phenotypes in Chronic Histiocytic Intervillositis: A Comprehensive Immunophenotypic and Morphologic Atlas.

International journal of molecular sciences·2026
Same author

Socioeconomic determinants of COVID-19 incidence in a German rural area.

BMC public health·2026

Related Experiment Video

Updated: Jan 29, 2026

A Protocol for Analyzing Hepatitis C Virus Replication
13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

24.7K

Advanced Hepatitis C Virus Replication PDE Models within a Realistic Intracellular Geometric Environment.

Markus M Knodel1, Paul Targett-Adams2, Alfio Grillo3

  • 1Department of Mathematics, Chair of Applied Mathematics 1, Friedrich-Alexander-Universität Erlangen-Nürnberg, Cauerstr. 11, 91058 Erlangen, Germany. markus.knodel@math.fau.de.

International Journal of Environmental Research and Public Health
|February 15, 2019
PubMed
Summary

This study models the hepatitis C virus (HCV) RNA replication cycle within intracellular factories. The enhanced model incorporates aggregate states and population dynamics, improving the understanding of viral reproduction and cis-replication requirements.

Keywords:
(surface) partial differential equations3D spatiotemporal resolved mathematical modelsFinite Volumescomputational virologyhepatitis C virus (HCV)massively parallel multigrid solversmathematical models of viral RNA cyclepopulation dynamicsrealistic geometriesviral dynamicswithin-host viral modeling

More Related Videos

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle
09:35

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle

Published on: February 1, 2017

13.9K
Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
09:02

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Published on: June 5, 2020

7.9K

Related Experiment Videos

Last Updated: Jan 29, 2026

A Protocol for Analyzing Hepatitis C Virus Replication
13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

24.7K
Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle
09:35

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle

Published on: February 1, 2017

13.9K
Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
09:02

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Published on: June 5, 2020

7.9K

Area of Science:

  • Virology
  • Computational Biology
  • Biophysics

Background:

  • Hepatitis C virus (HCV) RNA replication occurs in complex 3D intracellular structures called membranous webs (MW), derived from the Endoplasmic Reticulum (ER).
  • Visualizing and experimentally capturing this dynamic process is challenging.
  • Previous work established 3D spatiotemporal diffusion-reaction models for HCV RNA replication.

Purpose of the Study:

  • To extend existing 3D models of HCV RNA replication.
  • To incorporate aggregate states of viral RNA and non-structural proteins (NSPs).
  • To implement population dynamics-inspired diffusion and reaction coefficients for more realistic modeling.

Main Methods:

  • Developed surface partial differential equation (sPDE) models.
  • Integrated parameters for different aggregate states of HCV RNA and NSPs.
  • Utilized population dynamics-inspired coefficients for diffusion and reaction.

Main Results:

  • The extended model realistically simulates viral replication across scales.
  • A replication complex state comprising HCV RNA and NSPs was described.
  • The model qualitatively mimics a cis-replication requirement for HCV RNA.

Conclusions:

  • The enhanced model provides a more accurate representation of HCV RNA replication dynamics.
  • Findings support new modeling approaches and experimental investigations in virology.
  • The study advances understanding of virus-host interactions at the molecular level.